The Jacksonville Jaguars play Monday Night Football on Oct. 6 against the Kansas City Chiefs. Will Taylor Swift be part of the EverBank Stadium crowd?

Lloyd has arguably been the best performer on one of the NFL's best defenses through the first month of the season. Of the Jaguars' 13 takeaways, Lloyd has had four (three interceptions, one fumble recovery). He has come through again and again, and he is due to benefit from his career year sooner rather than later.

The NFL season continues with the San Francisco 49ers hosting the Jacksonville Jaguars Sunday. Start time, where to watch, streaming and NFL schedule.

Trevor Lawrence, Travis Hunter and the Jacksonville Jaguars go west to face the San Francisco 49ers in Week 4 NFL football. See updates and analysis.

The Jacksonville Jaguars came out on top of the San Francisco 49ers, ruining their perfect record this season.

Parker Washington had Jacksonville’s first punt return touchdown in eight seasons and the Jaguars opportunistic defense delivered four more takeaways in a 26-21 victory over the San Francisco 49ers on Sunday.

In yesterday's 26-21 loss to the Jacksonville Jaguars, San Franciso 49ers quarterback Brock Purdy accounted for three of the team's four turnovers.

The Jacksonville Jaguars' defense leads the NFL with 13 turnovers through the first four games of the season. Four turnovers against the San Francisco 49ers led to 17 points for the Jaguars' offense. According to Devin Lloyd, the players on the Jacksonville Jaguars' defense just might get to sleep each night by counting footballs, not sheep.

You've seen the model's best bets for San Francisco 49ers vs. Jacksonville Jaguars. Now, get against the spread, total and money-line picks for every Week 4 NFL game here, all from the model that's simulated every game 10,000 times.