We show that for thousands of years, humans have concentrated in a surprisingly narrow subset of Earth’s available climates, characterized by mean annual temperatures around ∼13 °C. This distribution ...

Koh et al. show that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is pathologically elevated in human and mouse Alzheimer’s disease (AD), traumatic brain injury (TBI), and aging, with 15-PGDH ...

Birds are charismatic—well loved, and highly studied. Many new phylogenies elucidating avian evolutionary relationships are published every year. We have united phylogenetic estimates from hundreds of ...

Mutualistic arbuscular mycorrhizal (AM) fungi provide plants with mineral nutrients in exchange for carbon. Plants tightly control AM symbiosis and microbial symbionts interfere with host signaling to ...

Brain stimulation has emerged as a potential therapeutic approach to correct or improve altered neural activity in Alzheimer’s disease. One such approach, 40 Hz sensory stimulation, or flicker, has ...

Algal biomass has been increasing in many lakes in recent years. These increases are thought to be due to climate change, potentially leading to regime shifts (large ecosystem responses to small ...

Excessive dust loading threats public health and food security and affects regional and global climate. This study reveals a robust and significant decrease in dust loading across West and South Asia ...

Multisystem coordination at barrier surfaces is critical for tissue functions and integrity, in response to microbial and environmental cues. In this study, we identified a neuroimmune crosstalk ...

Age-related cognitive decline is associated with metabolic, vascular, and inflammatory changes, making it challenging to distinguish primary causes from secondary (downstream) effects. This study ...

Antimicrobial resistance is a pressing global health challenge driven by human antibiotic consumption, among other factors. In this report, we investigate trends in human antibiotic consumption in 67 ...

Peto’s paradox—the puzzling disconnect between body size and cancer prevalence across species—has long stood as one of comparative biology’s most captivating and unresolved enigmas. Through the ...

Natural physical systems evolve with certain global quantities being minimized or maximized due to physical laws. For example, charges in conductors redistribute to reach electrostatic equilibrium, ...