In metastatic CRC, classifying p53 mutations as gain of function or non gain of function may predict sidedness dependent prognosis.

A robust non-parametric function fitting method is introduced. The estimate is motivated from the theory of M-estimation and of kernel estimation of regression functions. Consistency and asymptotic ...

PURPOSETo examine the impact of TP53 gain-of-function (GOF) and non-GOF mutations on prognosis of advanced pancreatic ductal adenocarcinoma (PDAC) among patients with KRAS, CDKN2A, and SMAD4 ...