Israel has escalated its bombardment of Iranian cities, including Tehran's state television headquarters; Iranian missiles have struck Tel Aviv.

Iran has two known underground nuclear enrichment sites, the one Israel attacked on the first day of its assault at Natanz, and another at Fordo. Both sit south of Tehran in central Iran, but Fordo has long been the Iranian nuclear facility of most concern to international monitors and experts.

Tehran faces the prospect of having to submit to a tougher negotiation on its nuclear program as its only way out of its confrontation with Israel.

WASHINGTON − President Donald Trump threatened Iran's supreme leader with assassination as he pushed Tehran to give up its nuclear enrichment program and air strikes continued over Iran and Israel.

An Israeli official said that "there's never a 100 percent guarantee," but "a nuclear disaster" should "not happen."

The head of the International Atomic Energy Agency says there is a possibility of both radiological and chemical contamination within Iran’s main nuclear enrichment facility in Natanz.

Israel and Iran attacked each other for a fifth straight day on Tuesday, and U.S. President Donald Trump urged Iranians to evacuate Tehran, citing what he said was the country's rejection of a deal to curb nuclear weapons development.

There will be no nuclear talks with Iran on Sunday, a senior U.S. administration official says, adding Washington still hopes Tehran will resume negotiations soon. “We remain committed to talks and hope the Iranians will come to the table soon,