Intracranial aneurysms are common, and the risk of rupture is influenced by size, location, morphology, and factors such as ...

To access our most recent research and articles on Covid-19 and Covid-19 vaccines, please visit the NEJM Coronavirus (Covid-19) page. To realize the potential of recently developed Covid-19 ...

This review article series focuses on fundamental and emerging concepts in nutrition, from the basic “pharmacodynamics” of food to evolving understanding of the gut and immunity and the role ...

In this review, we discuss evolving concepts in the diagnosis and prognosis of alcohol-associated hepatitis, the current trend to treat these patients in a holistic manner involving addiction ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

In 1974, Nobel Laureates Sherwood Rowland and Mario Molina predicted that the increasing use of chlorofluorocarbons (CFCs) in foam insulation, refrigeration, and aerosols including metered-dose ...

Adverse events during hospitalization are a major cause of patient harm, as documented in the 1991 Harvard Medical Practice Study. Patient safety has changed substantially in the decades since ...

Dr. Daniel A. Zlotoff: A 44-year-old woman was admitted to this hospital because of shortness of breath and chest pain. Eight days before admission — and 3 days after her husband had begun to ...

Phenotypes Acute hepatic necrosis, serum enzyme elevations, sinusoidal obstruction, acute fatty liver, nodular regeneration Acute hepatocellular hepatitis, mixed or cholestatic hepatitis, bland ...

Dupilumab (interleukin-4Rα; antibody binds to interleukin-4Rα, inhibiting interleukin-4 and interleukin-13 signaling in hematopoietic cells [e.g., B cells, CD4+ helper T cells, and eosinophils ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration ...