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PyCharm also lets you configure test configurations to manage how your tests are run. You can specify which tests to run, which Python interpreter to use, and other options.
It looks like the plugin will use the system python instead of the virtual env that my project uses. I have a project that uses uv and automatically sets up an environment under the .venv folder.
My copy of PyCharm (Professional 2020.02 on macOS Catalina) does not see the virtual environment on first opening a project. I am running Python version 3.8.5, installed in /usr/local/bin by HomeBrew.